Thermo Scientific OmniPATH COVID-19 Total Antibody ELISA Test
In a single test, the Thermo ScientificTM OmniPATHTM COVID-19 Total Antibody ELISA Test provides a comprehensive look at the adaptive antibody immune response to SARS-CoV-2, the virus that causes COVID-19, by detectingantibodies to the receptor binding domain (RBD) of the S1 subunit of the spike (S) protein.
Why the spike (S) protein RBD?
The spike protein is a major antigen target of vaccines.Antibodies that detect the RBD are more likely to be neutralizing. Compared to other SARS-CoV-2 proteins,the RBD has less similarity to other coronaviruses,which can provide diagnostic specificity advantages.
Why a total antibody test?
Combined detection of IgG with other isotypes may improve serology sensitivity early in course of COVID-19. Total antibody testing can detect both long-term (IgG)and more transient (IgA, IgM) antibody isotypes, thus providing an overall picture of SARS-CoV-2 antibody response, whether the infection happened more recently,or several months ago.